microdosing
Psychedelics and Neuroplasticity: How Psilocybin, Ayahuasca, and DMT Rebuild the Brain
For most of the twentieth century, neuroscience operated under a grim assumption: the adult brain was essentially fixed. Once the critical periods of childhood development closed, the brain's wiring was set.
Terence McKenna's Stoned Ape Theory: How Psilocybin Mushrooms May Have Catalyzed Human Consciousness
Terence Kemp McKenna (1946-2000) was many things: ethnobotanist, psychonaut, author, lecturer, and the most eloquent spokesperson for the psychedelic experience that the English language has ever produced. But his most enduring contribution was a single hypothesis — an idea so radical that...
The Flow Genome Project: Mapping Ecstasis Across Navy SEALs, Silicon Valley, and Extreme Athletes
Something happened in American high-performance culture in the early 21st century that few people noticed until Steven Kotler and Jamie Wheal documented it. Across seemingly unrelated domains — the military, Silicon Valley, extreme sports, and the psychedelic underground — elite performers had...
Microdosing Psychedelics: The Nootropic Frontier Between Placebo and Neuroplasticity
In the sprawling landscape of cognitive enhancement, no practice generates more controversy, more enthusiasm, and more methodological confusion than microdosing — the regular ingestion of sub-perceptual doses of psychedelic compounds, typically psilocybin or LSD, for the purpose of enhancing...
Microdosing: Science and Practice
Microdosing — the practice of consuming sub-perceptual doses of psychedelic substances on a regular schedule — has emerged as one of the most culturally visible and scientifically contested phenomena in the modern psychedelic renaissance. Popularized by James Fadiman's 2011 book The Psychedelic...
Psychedelic-Assisted Therapy: A Clinical Framework
After four decades of prohibition, psychedelic substances are returning to clinical medicine — not as counterculture relics but as the most significant breakthrough in psychiatric treatment since the development of SSRIs. The research is emerging from the world's most rigorous institutions —...
The Tryptamine Molecular Family: One Scaffold, the Entire Spectrum of Consciousness
If you could zoom in on the molecular machinery of consciousness — the actual chemical architecture that produces your mood, your sleep, your dreams, your sense of self, your capacity for mystical experience — you would find, at the center of it all, a single molecular template repeated with...