NAD+

Biology of Aging and Longevity

Aging is simultaneously the most universal human experience and one of the least understood biological processes. Every human being ages, yet the fundamental mechanisms driving the progressive decline in physiological function, the increasing vulnerability to disease, and the ultimate limit on...

Traditional Longevity Practices

While modern geroscience searches for pharmacological interventions to extend human lifespan, several populations around the world have achieved extraordinary longevity through lifestyle and cultural practices that long predate the laboratory. Dan Buettner's Blue Zones research — identifying...

Chronic Fatigue Syndrome and Fibromyalgia: Unraveling the Invisible Illnesses

Chronic fatigue syndrome (CFS/ME — myalgic encephalomyelitis) and fibromyalgia represent two of the most misunderstood, misdiagnosed, and stigmatized conditions in modern medicine. CFS/ME affects an estimated 17-24 million people worldwide, while fibromyalgia affects approximately 2-4% of the...

Exercise and Epigenetics: How Movement Rewrites Your Genetic Expression

The Human Genome Project was completed in 2003 at a cost of three billion dollars, mapping all 20,000-25,000 protein-coding genes in human DNA. The implicit promise was that decoding the genome would unlock the secrets of disease, aging, and human biology.

Hormesis: How Controlled Stress Builds Consciousness Resilience at the Cellular Level

There is a paradox at the heart of biology that most health advice ignores: some stress makes you stronger. Not all stress.

Autophagy and Consciousness: How Fasting Triggers the Brain's Cellular Cleanup System

In 2016, the Nobel Prize in Physiology or Medicine was awarded to Yoshinori Ohsumi, a Japanese cell biologist at the Tokyo Institute of Technology, for his discoveries of the mechanisms of autophagy. The word "autophagy" comes from the Greek auto (self) and phagein (to eat) — self-eating.

Dry Fasting: The Most Extreme Fasting Practice — What the Science Says and What It Does Not

In the landscape of fasting practices, dry fasting occupies the extreme edge — the territory where the boldest claims are made, the least research exists, and the potential for both benefit and harm is greatest. Dry fasting means abstaining from both food and water for a defined period.

Long COVID: The Functional Medicine Framework

COVID-19 was an acute crisis. Long COVID is a chronic one.

The 12 Hallmarks of Aging: A Functional Medicine Map

For most of medical history, aging was treated like weather — something that just happens to you. You get old, things break down, you manage the wreckage.

Senolytics, NAD+, and the New Science of Longevity

Inside your body right now, there are cells that have stopped dividing but refuse to die. They sit in your tissues — fat, skin, joints, lungs, blood vessels — secreting a toxic cocktail of inflammatory molecules, tissue-degrading enzymes, and growth factors that corrupt their neighbors.

Mitochondrial Optimization Protocol

Two billion years ago, a primitive cell swallowed a bacterium. Instead of digesting it, the two formed an alliance.

IV Therapy Protocols in Functional Medicine

The gastrointestinal tract is a magnificent, tortuous obstacle course. Oral vitamin C achieves maybe 20% bioavailability — your enterocytes have saturable sodium-dependent transporters (SVCT1) that impose a hard ceiling.

Blue Zones: Where Consciousness Outlives the Body's Expected Warranty

In the early 2000s, demographer Michel Poulain and physician Gianni Pes identified a region of Sardinia, Italy, with an extraordinary concentration of male centenarians — ten times the rate found in the rest of Italy. They circled the area on a map with blue ink, and the term "Blue Zone" was born.

Caloric Restriction: The Most Ancient Longevity Mechanism and Its Consciousness Connection

Long before rapamycin was extracted from Easter Island soil, long before NAD+ was identified as a coenzyme, long before anyone knew what a telomere was, one intervention had already been shown to extend lifespan more consistently than any other: eating less.

NAD+ and Sirtuins: The Cellular Energy Currency of Longevity and Consciousness

Imagine your body as a massive data center — trillions of processors running simultaneously, each requiring a constant power supply. Now imagine that the power grid feeding this data center loses approximately 50% of its capacity between ages 40 and 60.