Karl Friston
Biological Computationalism: The Third Path to Consciousness
The philosophy of consciousness has been stuck in a binary trap for decades. On one side: functionalism (classical computationalism), which holds that consciousness is substrate-independent computation — that any system implementing the right algorithm, whether silicon or carbon, would be conscious.
Consciousness Science at the Crossroads: From the Hard Problem to the Engineering Era
In 1994, David Chalmers stood before an audience at the first Tucson conference on consciousness and articulated what he called the "hard problem" — why does subjective experience exist at all? Why is there something it is like to see red, feel pain, taste coffee?
Psychedelic Neuroplasticity Breakthroughs: The Fastest Brain Rewiring Ever Observed
By 2025, the scientific evidence has become overwhelming: psychedelic compounds are the most powerful neuroplasticity inducers ever discovered. A single dose of psilocybin produces structural brain changes — new dendritic spines, new synaptic connections, reorganized neural networks — within 24...
Psychedelic-Assisted End-of-Life Care: Psilocybin, Mystical Experience, and the Dissolution of Death Anxiety
In 2016, two landmark studies — one from Johns Hopkins University, one from New York University — reported results that would have seemed impossible a decade earlier: a single dose of psilocybin, administered in a controlled clinical setting with psychological support, produced rapid,...
The Neurochemistry of Ego Dissolution: The Chemical Pathway from "I" to "No-I"
There is a moment — accessible through psychedelics, through advanced meditation, through spontaneous grace — when the sense of being a separate self dissolves. The boundary between "me" and "everything else" becomes transparent, then permeable, then irrelevant.
Open-Label Placebo: The Breakthrough That Broke the Model
For decades, the placebo effect was understood through a simple equation: deception equals healing. The patient must believe they are receiving a real treatment.
The Neuroscience of Psychedelics
The scientific study of psychedelic compounds has undergone a remarkable renaissance since the early 2010s, producing some of the most significant advances in our understanding of consciousness, neural connectivity, and brain plasticity in modern neuroscience. Classic psychedelics — psilocybin,...
The Psychedelic Renaissance in 2025: A Complete Map of the Field
The psychedelic renaissance — the resurgence of scientific and clinical interest in psychedelic compounds after decades of prohibition — has by 2025 matured from a fringe movement into a legitimate biomedical field with billion-dollar valuations, FDA breakthrough therapy designations, published...
REBUS and the Entropic Brain: How Psychedelics Rewrite Reality
In 2019, Robin Carhart-Harris and Karl Friston published what has become the most influential theoretical paper in psychedelic science: "REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics" in Pharmacological Reviews. The paper synthesizes two frameworks —...
Psychedelic Sexuality and Boundary Dissolution: When the Self-Other Divide Melts
There are two experiences in human life that reliably dissolve the boundary between self and other: sexual ecstasy and psychedelic states. Both produce what researchers call "boundary dissolution" — a softening or complete collapse of the felt sense of where "I" end and the world begins.
Perception and Reality Creation
You are hallucinating right now. Not in the clinical sense — in the neurological sense.